Supplementation With Nattokinase May Decrease Plasma Levels of Fibrinogen, Factor VII and Factor VIII

Keywords:	CARDIOVASCULAR DISEASE - Nattokinase, Fibrinogen, Factor VII, Factor VIII
Reference:	"Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects," Hsia CH, Yang NC, et al, Nutr Res, 2009; 29(3): 190-6. (Address: Division of Cardiovascular Medicine, Changhua Christian Hospital, Changhua 500, Taiwan).
Summary:	In a study involving 45 participants (healthy volunteers, patients with cardiovascular risk factors, and patients undergoing dialysis), results indicate that supplementation with nattokinase may decrease plasma levels of fibrinogen, factor VII, and factor VIII. The subjects received 2 capsules of nattokinase per day (2000 fibrinolysis units per capsule) for a period of 2 months. At intervention end, plasma levels of fibrinogen, factor VII and factor VIII decreased similarly in all subjects (fibrinogen 7-10%, factor VII 7-14%, factor VIII 17-19%). Thus the authors conclude, "In summary, this study showed that oral administration of nattokinase could be considered as a CVD nutraceutical by decreasing plasma levels of fibrinogen, factor VII, and factor VIII."