Antioxidants Reduce Inflammation

Antioxidants Reduce Inflammation

Keywords:INFLAMMATION - Antioxidants, Coenzyme Q9, Coenzyme Q10, Alpha-Tocopherol, Vitamin E, Beta-Carotene

Reference:“Naturally occurring antioxidant nutrients reduce inflammatory response in mice,” Novoselova EG, Lunin SM, et al, Eur J Pharmacol, 2009; 615(1-3): 234-40. (Address: Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region 142290, Russian Federation. E-mail: elenanov_06@mail.ru ).
Summary:In a study involving NMRI male mice, supplementation with the fat-soluble antioxidants, coenzyme Q9, alpha-tocopherol, and beta-carotene, for 15 days prior to being induced with acute inflammation (through lipopolysaccharide injection - which induced production of pro-inflammatory cytokines) was found to significantly reduce the level of inflammation induced by the lipopolysaccharide injection, as compared to levels found in mice who did not receive the antioxidants. In addition, antioxidant treatment was associated with a significantly reduced expression of the inducible form of heat-shock protein 70, induced by the injection as well. The authors conclude, “In this report we demonstrate the potential effectiveness of naturally occurring antioxidant nutrients in the reduction of the inflammatory response. Therefore, it may be possible to develop novel therapeutic combinations, containing coenzyme Q(9), alpha-tocopherol, and beta-carotene, which promote immune stimula tion.”