Monday, November 22, 2010

Apolipoprotein E Genotype and Concussion in College Athletes

Clinical Journal of Sport Medicine:
November 2010 - Volume 20 - Issue 6 - pp 464-468
doi: 10.1097/JSM.0b013e3181fc0a81
Original Research

Apolipoprotein E Genotype and Concussion in College Athletes

Tierney, Ryan T PhD, ATC*; Mansell, Jamie L MEd†; Higgins, Michael PhD‡; McDevitt, Jane K MS*; Toone, Nieka MS*; Gaughan, John P PhD§; Mishra, Anarug PhD¶; Krynetskiy, Evgeny PhD¶

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Objective: To evaluate the association between apolipoprotein E (APOE) polymorphisms (E2, C/T Arg158Cys; E4, T/C Cys112Arg; and promoter, g-219t) and the history of concussion in college athletes. We hypothesized that carrying 1 or more APOE rare (or minor) allele assessed in this study would be associated with having a history of 1 or more concussions.

Design: Multicenter cross-sectional study.

Setting: University athletic facilities.

Participants: One hundred ninety-six male football (n = 163) and female soccer (n = 33) college athletes volunteered.

Interventions: Written concussion history questionnaire and saliva samples for genotyping.

Main Outcome Measures: Self-reported history of a documented concussion and rare APOE genotype (E2, E4, promoter).

Results: There was a significant association (Wald χ2 = 3.82; P = 0.05; odds ratio = 9.8) between carrying all APOE rare alleles and the history of a previous concussion. There was also a significant association (Wald χ2= 3.96, P = 0.04, odds ratio = 8.4) between carrying the APOE promoter minor allele and experiencing 2 or more concussions.

Conclusions: Carriers of all 3 APOE rare (or minor) alleles assessed in this study were nearly 10 times more likely to report a previous concussion and may be at a greater risk of concussion versus noncarriers. Promoter minor allele carriers were 8.4 times more likely to report multiple concussions and may be at a greater risk of multiple concussions versus noncarriers. Research involving larger samples of individuals with multiple concussions and carriers of multiple APOE rare alleles is warranted.

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